Excerpts from The Testosterone Syndrome

“The Critical Factor for Energy, Health, and Sexuality - Reversing the Male Menopause”

In 1998 Dr. Eugene Shippen authored a book entitled “The Testosterone Syndrome” where he presented extensive evidence documenting the crucial role of testosterone in men's health, vitality, and sexual function. Since its publication nearly fifteen years ago, there have been countless studies that not only support his early findings, but go even further in revealing the importance of maintaining optimal testosterone levels for health and longevity.

The Testosterone Syndrome was welcomed with open arms by legions of men who had been told for decades that their debilitating symptoms were just a natural part of the aging process. Increased body fat, decreased muscle, low sex drive, poor sexual performance, aches, pains and a variety of symptoms that their family doctors told them they’d have to learn to live with.

The book was praised by those who were told it was time to be put out-to-pasture by a medical establishment that would much rather hand out anti-depressants than encourage them to take their life and health into their own hands.

"What you'll need, if you plan to get back some of your youth and hold onto every scrap of your health, is a physician who believes in the value of hormone testing and treatment and who is willing to work with you to determine your present physical status." - Dr. Shippen

Following are some excerpts from this landmark publication:

“If I told you that one key substance in the body is more powerful than any other health factor, is more closely linked to risk of illness if and when deficiency occurs, is more misunderstood, more improperly used, and more tragically underused than any other, what would it be? Testosterone! I have studied it, prescribed it, and watched the responses of my patients-hundreds of them. I challenge anyone to find a more diversely positive factor in men’s health. When normally abundant, it is at the core of energy, stamina, and sexuality. When deficient, it is at the core of disease and early demise.”

Here Dr. Shippen speaks about the debilitating effects of Low T and how established medicine has kept men in-the-dark regarding the relief that was available to them through testosterone replacement therapy.

“Testosterone deficiency has been an unrecognized syndrome that impacts every sinew and cell in the body. It is powerfully linked to nearly every major degenerative disease. Use of this remarkably healthy hormone could reverse suffering and prevent early death. My research uncovered a mountain of medical literature that has been basically ignored supporting its benefits.

I was taught that there was no male menopause and for years accepted that as fact. A series of events in my own health and the discovery that several pioneering physicians held entirely different points of view changed my mind and transformed my conception of age-related illness and preventive medicine. Until that point, I had seen aging as an unrelenting natural process that it was best to accept gracefully. Preventive medicine was an attempt to treat or modify specific risk factors that, like a sleeping lion, would jump up and bite you later in life.

My perspective changed dramatically. Clearly, preventive medicine would widen in scope if it turned out aging was reversible. And, to a significant extent, it is. The male menopause, a grim milestone in the middle passage of a man’s life, can be rolled back.”

Menopause: Not Just for Women Anymore!

“Testosterone decline is at the core of that male menopause (and a key element to female menopause as well). Naturally, the two sexes have a different experience of midlife menopausal change. In women, there is an explosion of in-your-face symptoms, while men’s very similar symptoms sneak in the back door unexpectedly like a thief in the night. Too often, loss of energy, ambition, sexual drive, and a host of minor symptoms are written off as “burnout” or depression.

Women, meanwhile, have already learned that hormone replacement results in reversal of the physical changes of menopause. Men, confronted by an information vacuum, still need to make the same discovery.”

Do You Know What A Hormone Is?

“A hormone is a chemical substance produced in one part or organ of the body that starts or runs the activity of an organ or a group of cells in another part of the body. Testosterone, estrogen, insulin, adrenalin, cortisonethese are a few of the hormones found in most people’s vocabularies and at least vaguely understood.

Hormones can also be converted from one hormonal substance into another out in the tissues of the body. This is a newer concept, which later in the book will prove vital, and is referred to as intracrinology. In the last few years, the popular anti-aging literature has given many people a familiarity with such hormones as DHEA, growth hormone, and melatonin. They are generally important substances, and perhaps some of you are already familiar with the idea that the levels of hormones can affect our actual (as opposed to chronological) rate of aging. Every cell in the human body is programmed by hormonal messengers.

Hormones tune our systems-or detune them. We are hormonal creatures to at least as great an extent as we are oxygen-breathing creatures or blood-circulating creatures. We could not live a day or hardly even an hour without properly balanced hormonal input. Balance is the crucial word. Too much of the more important hormones would burn us out metabolically at a fantastic rate. Too little and our systems begin to slowly shut down.

Think back when you were young. If you were like most people, you reached your physical peak in your late teens or early twenties. It was a time of rambunctious energy that resisted every effort to squander it away. Late nights, too much work and too much play, and, for many of us, far too much eating and drinking-all this produced very little in the way of untoward effects. For many twenty-year-olds, burning the candle at both ends is not a danger; it’s an art form. Pushing past every reasonable limit, we recharged our cellular batteries as fast as we drained them. How were our organ systems and indeed, every cell in our bodies able to keep up with the brutal pace? Hormones! We were in hormone heaven.”

Hormones drop significantly and steadily from year to year and decade to decade:

“The optimal function of every cell requires optimal hormonal input - and we had it. Logically, therefore, any decline in hormonal activity from youthful norms will result in suboptimal cellular activity. Does that seem reasonable? We know that it is. There are many reasons hormones change, including illness, stress, the autoimmune destruction of our glands, and of course, the natural decline of aging. Any doctor who has carefully charted the hormonal changes of his patients knows the significant, long term hormonal decline leads irresistibly toward illness, fatigue, malaise, and further aging. And any doctor who looks for hormonal decline will find hormonal decline. Most of the major hormone system drops significantly and steadily from year to year and decade to decade. It is one of the most important parts of the steady downward spiral into old age and debility.

It would be impossible to overemphasize the devastating effects that the menopause has on millions of men and women. Doctors know because people come and sit in our offices and tell us secrets that they wouldn’t even whisper to their spouses. And once you’ve listened for a while to people telling you that their sex lives are crumbling, their energy is shattered, their health is growing shakier by the year-and one soon finds out that they’re right on that point-one feels a very real compulsion to do something about it.

Is all this unpleasant change menopause? A whole lot of it is. Heart disease, high blood pressure, diabetes, arthritis, osteoporosis- indeed, most of the major risk factors for dying –are all intimately related to hormonal changes. To a surprising degree many of these dreadful conditions reverse themselves when a proper balancing of the hormones in the body is combined with sensible diet. To say that the menopause is natural seems like a trivial distinction in the face of these calamities. Death is natural and inevitable; too, many of us would like to postpone it. Moreover, I think I speak for most people when I say we would like to keep our youthful vigor throughout our lives, right up to the end.”

Dr. Shippen on Turning Back the Clock:

“Most likely you think this sounds bizarre. Reverse aging? Surely it’s just as easy to tell the sun to stand still. Not really. It’s certainly true that in the past nothing could be done about aging. You knew that whatever way you felt at the present time, you were certainly going to feel a little older in a year or two. The process was irreversible, steady, and downhill.

This simply isn’t true any longer. A carefully planned program of diet, exercise, and hormonal replacement can make you feel much younger and healthier in a year or two from now than you do today. I’ve seen it happen faster than that. And the lucky people who experienced these changes weren’t younger in their own minds.

Their outward appearance, their metabolic functioning as measured by lab tests, their everyday standard of behavior, energy, attitude, and drive - were all testimony to the fact that, for a while at least, they would enjoy the very special pleasure of spitting in the face of the calendar.”

A detailed self-test to see if you may be suffering from a testosterone deficiency:

“Before we consider whether you, too, can objectively speaking make yourself feel younger, it makes good sense to establish a personal baseline. There are clusters of significant symptoms in such areas as brain function, sex function, general metabolic condition, and musculoskeletal wellness that go a long way toward determining how far you’ve traveled from the blithe days of your youth. I want you to look at the symptoms outlined below and, to the best of your knowledge, decide whether you’ve seen noticeable or significant declines in any of these areas of function in the years since you turned thirty. It is, of course, perfectly normal to see a certain amount of decline in some aspects of physical function.

Nobody’s perfect; we all age, and certainly, not many people are as athletic at fifty-five as they were at thirty-five. In fact, at the high end of functionality, nobody is. Nonetheless, if you find yourself racking up too many moderate or major decreases in function, that probably indicates that you’re aging faster than you need to, and it may well reflect hormonal decline. So please make an effort, examine your physiological conscience, and let’s see how many times you answered yes.”

Questions for Treatment:

Do you currently have or ever had any of the following symptoms? Yes or No?

Sex Function

  • Decrease in spontaneous early morning erections?
  • Decrease libido or desire for sex?
  • Decrease in fullness of erections?
  • Decrease in volume of ejaculate or semen?
  • Decrease in strength of climax or force of muscular pulsations?
  • Difficulty in maintaining full erection?
  • Difficulty in starting erection?or no erection?

Mental Functions

  • Spells of mental fatigue or inability to concentrate; feeling burned out?
  • Tiredness or sleepiness in the afternoon or early evening?
  • Decrease in mental sharpness, attention, wit?
  • Change in creativity or spontaneous new ideas?
  • Decrease in initiative or desire to start new projects?
  • Decreased interest in past hobbies or new work?related activities?
  • Decrease in competitiveness?
  • Change in memory function; increased forgetfulness?
  • Feelings of depression?

Musculoskeletal Condition

  • “Sore?body syndrome”?aches, joint and muscle pain? Decline in flexibility and mobility; increased stiffness?
  • Decrease in muscle size, tone, strength?
  • Decrease in physical stamina?
  • Decrease in athletic performance?
  • Back pain; neck pain?
  • Tendency to pull muscles or get leg cramps?
  • Development of osteoporosis or inflammatory arthritis?

Metabolic or Physical/Disease Problems

  • Increase in total cholesterol or triglycerides?
  • Decrease in HDL cholesterol? Rise in blood sugar level diabetes onset?
  • Rise in blood pressure/ diagnosis of hypertension?
  • Unexplained weight gain, particularly in the midsection; “beer belly”?
  • Increased fat distribution in breast area or hips?
  • Development of chest pain, or diagnosis of heart disease or blockage of arteries?
  • Shortness of breath with activities; worsening of asthma or emphysema?
  • Lightheadedness, dizzy spells, ringing of the ears; new onset of headaches?
  • Poor circulation in legs, swelling of ankles, varicose veins or hemorrhoids?
  • Changes in visual acuity focus reading fine print?


How did you do?

If you’ve seen significant declines in any of these functions you may have Low T and should have your testosterone levels checked, but remember, a testosterone level that is entirely satisfactory for one man may leave another man feeling old and unmanly. The only person who can truly know what is “normal” for them is the rare man who happened to have his baseline testosterone level determined in early adulthood. For the rest of us, it’s the symptoms that tell the tale. Symptoms that are treatable and in many cases reversible.

Excerpts from "The Testosterone Syndrome: The Critical Factor for Energy, Health, and Sexuality " by Eugene Shippen, MD

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